Amino 2,3 dihydro 2 methyl 1 H indole hydrochloride(ⅲ) was obtained by the reaction of 2,3 dihydro 2 methyl 1 H indole with ⅱ, yield 81 7%. 2,3-二氢-2-甲基-1H-吲哚与()反应生成1-氨基-2,3-二氢-2-甲基-1H-吲哚的盐酸盐(),产率81.7%;
Indapamide(ⅳ) was prepared by four step reactions, starting from 4 chloro 3 sulphamoyl benzoic acid, 1 amino 2,3 dihydro 2 methyl 1 H indole and hydroxylamine O sulphonic acid. 以4-氯-3-磺胺基苯甲酸,2,3-二氢-2-甲基-1H-吲哚和硫酸羟胺为原料,经4步反应合成了降压新药吲哒帕胺。
Methods 2-naphthylhydrazine was prepared from 2-naphthylamine via diazotization and reduction reactions, followed by a Fischer indole synthesis with isopropyl methyl ketone to give 1,1,2-trimethyl-1H-benz [ e] indole. 方法由2-萘胺经重氮化反应、还原反应制得2-萘肼,再与甲基异丙基酮经费歇尔吲哚合成反应制得目标化合物。